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Macrovascular Disease (3,19,22)
In this disease, medium to large size vessels become blocked (atherosclerosis) or vessel walls thicken (arteriosclerosis) reducing or blocking the flow of blood. These vessels supply blood to the legs (peripheral vascular disease), brain (cerebral vascular disease) heart (coronary vascular disease). Cardiovascular disease is the leading cause of illness and death among all diabetics. In diabetics, cardiovascular disease is more likely to occur earlier in life and is more often fatal than in non-diabetics. Risk of heart disease may also be greater in Type 1 diabetics. Several risk factors, obesity, cholesterol level, inactivity, hyperinsulinemia combined with diabetes put an individual more at risk for developing cardiovascular disease.
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